Welcome to your IBRANCE^® (palbociclib) tablets monthly box.

As you may already know, these smooth-coated tablets have the same active ingredient as the capsules, and are lactose and gelatin free. And, unlike the capsules, you can take IBRANCE tablets with or without food.

The tablets come in three dosage strengths: 125 mg, 100 mg, and 75 mg.

So your child-resistant blister packaging will come in the box that’s the dose strength prescribed for you. Inside every IBRANCE box, you’ll find: an insert, which summarizes the treatment instructions, and your three individual weekly packs of IBRANCE tablets to use throughout your treatment cycle. It’s important to use only one pack per week.

Each pack includes dosing instructions on the left, and a schedule tracker on the right.

Take one pack out of the box and circle “Week 1.” This will remind you to use this pack for the first week of your 4-week cycle.

Now circle "Week 2" and "Week 3" on the inside of the other two packs.

This will help you to be sure to use the right pack each week.

Remember, IBRANCE is taken for 3 weeks in a row, and during the 4th week of the cycle no IBRANCE is taken.

As always, follow your dosing schedule for IBRANCE and your combination treatment exactly as your healthcare team prescribes.

Start with the first pack during the first week, and with the tablet marked with the appropriate day of the week. Take one tablet of IBRANCE daily, at the same time every day, until the pack is finished.

Only store your IBRANCE tablets in the original blister packaging, and do not remove the tablet until it is time to take your dose.

Always swallow the tablets whole, and do not take any tablets that are broken or damaged.

To remove your IBRANCE tablets from the package, try one of these simple methods: Note, while packaging colors and tablet sizes may vary, these techniques will work for all of them.

Also, for all three techniques, make sure you hold your hands over a table.

Method One.

Unfold the blister pack.

Next, cup one hand and hold it under the tablet that you want to remove.

Using your opposite hand, place your thumb over the foil and push to release the tablet into your cupped hand.

If the tablet does not push all the way through, peel back the paper underneath.

Method Two.

Hold the center sleeve in both hands.

Find the tablet for the appropriate day of the week.

Apply equal pressure to the blister with both thumbs until the tablet is pushed through the foil.

Again, if the tablet does not push all the way through, just peel back the paper underneath.

Method Three.

Take two fingers and place them over the foil for the tablet that you wish to take, keeping your two thumbs underneath the blister pack.

Now, without letting go, flip the blister pack over so that your thumbs are now on top.

Apply equal pressure to the foil covering the tablet with your fingers and push the tablet up towards your thumbs.

And just like the last two methods, you can always peel back the paper if the tablet does not push all the way through.

If you have questions, speak with your healthcare provider or pharmacist.

Thanks for watching.